Profhilo

What is Profhilo?

Profhilo is the first BDDE-free stabilised injectable hyaluronic acid (HA) based product for treating skin laxity. With one of the highest concentrations of HA on the market (64mg / 2ml) it is not only boosting and hydrating the skin, but also remodels the ageing and sagging tissue. Profhilo delivers great results as a treatment on its own or in combination with other aesthetics treatments currently on offer.

Expert View

Dr Emma Ravichandran says: “Anyone who presents with signs of skin ageing and is suitable for dermal filler treatment is also suitable for treatment with Profhilo. Once injected, the product immediately starts spreading due to the high concentration of HA and its cohesive nature. The BAP technique is an extremely effective and simple technique to use for injectors who are not comfortable with the use of cannulas.”

How does Profhilo work?

As a stabilised product Profhilo lasts in the skin around 28 days. During this time the stimulation of 4 different types of collagen and elastin takes place by slow release of HA. The stimulation results in significant tissue improvement. Therefore we cannot say that Profhilo is a skin booster as it also has a significant tightening / lifting effect on the tissue.

Unique Product

There are many characteristics that make Profhilo unique from anything else available on the market right now. There is no BDDE content. It is thermally cross-linked generating stabilised hybrid co-operative complexes of H-HA and L-HA. Despite its high HA content, it has a low inflammatory profile coupled with pro-healing properties backed by clinical studies. To fully understand this new concept in anti-ageing medicine we have to take a look at the technology first.

Advantages

In Profhilo, L-HA is released slowly from the HA hybrid complexes and therefore does not trigger the first inflammatory cytokines making it very biocompatible. It also increas¬es patient comfort during and after treatment and provides hydration to the skin especially in the epidermis – the Hydro effect.

H-HA in Profhilo provides a stable HA architecture in the dermis. This gives a volumetric effect – the Lift effect.

Another advantage of the stable co-operative hybrid complex when compared to H-HA and L-HA is the increase in the ex¬pression levels of type I and type III collagen in fibroblast and type IV and VII collagen in keratinocytes.

This results in improved skin quality and skin hydration both in the dermis and epidermis. There is also increased production of endogenous HA and elastin giving the skin a more youthful look.

Highest Concentration on the market

Profhilo contains 32mg of low molecular weight HA (80-100Kda) and 32 mg of high molecular weight HA (1100-1400Kda). This gives one of the highest concentration of HA on the market totalling 64 mg of HA in a 2ml prefilled syringe. Remarkably this can still be extruded using a 29g needle.